PR3-ANCA associated vasculitis with rapidly progressive glomerulonephritis (RPGN): an uncommon cause of rapidly developing renal failure

Abstract

PR3-ANCA-associated vasculitis is a rare autoimmune disease characterized by systemic inflammation, primarily affecting the respiratory tract but occasionally leading to rapidly progressive glomerulonephritis (RPGN). We present the case of a 64-year-old male with diabetes, hypertension, and COPD, who developed RPGN and pulmonary manifestation, initially manifesting as frothy urine, pedal edema, and dyspnoea. Diagnostic evaluation revealed positive PR3-ANCA, proteinuria, hematuria, and significant renal pathology, necessitating hemodialysis and immunosuppressive therapy with cyclophosphamide . This case underscores the need for early recognition and tailored management of PR3-ANCA vasculitis to improve patient outcomes.